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Skin Optimized Retinoid Serum

(28 customer reviews)


Powerful yet gentle, the most effective retinoid serum on the market.


SKU: 785 Category:


This unscented lightweight hydrating serum is in a highly-absorptive skin microbiome friendly formula that delivers dramatic results for aging and acne-prone skin. The Skin Optimized Retinoid Serum helps renew skin plumpness and elasticity gently and effectively. It also reduces breakouts and hyperpigmentation, leaving the skin refreshed and radiant. Our advanced retinoid formula helps rebuild skin’s collagen while filling in lines and wrinkles. This optimized formula is far less irritating than other conventional forms of retinol making it a great choice for sensitive skin.


  • Skin microbiome friendly via NuVsio Skin Optimized Technology
  • Advanced retinoid formula for sensitive skin
  • Helps renew skin plumpness & elasticity
  • Reduces breakouts and hyperpigmentation*
  • Overtime helps rebuild skin collagen & reverses sun damage*
  • Helps produce more supple & younger looking skin*

Great for all skin types. Vegan, cruelty-free, gluten-free, fragrance-free, oil-free, and silicone-free.

*Individual results may vary

Additional Info

It is recommended to use the Skin Optimized Retinoid Serum in the evening on a cleansed skin before applying the Mineral Enriched Balm Concentrate. Apply one pump to the face and let it absorb prior to subsequent cream/balm/oil application. Do not use with other retinoid treatments and use a minimum of 15 SPF sunscreen during the day.

Special note: Be sure to use SPF 15 or greater protection during the day. Do not use this product together with other retinoid products (retinol or retinoic acid). Acne-prone skin may experience breakouts during the first few weeks of use of this and other retinoid products.

Aqua**, Simmondsia Chinensis (Jojoba) Seed Oil*, Argania Spinosa (Argan) Kernel Oil*, Punica Granatum (Pomegranate) Seed Oil*, Glycerin**, Stearyl Olivate**, Sorbitan Olivate**, Dimethyl Isosorbide**, Xanthan Gum**, Retinol (advanced), Tocopherol (D-Alpha, Beta, Gamma, Delta)**, Benzyl Alcohol**, Salicylic Acid**, Sorbic Acid**, Ascorbic Acid**. *Organic/biologique. *Certified Organic **Naturally Sourced

28 reviews for Skin Optimized Retinoid Serum

  1. Ronny

    Great at minimizing fine lines and wrinkles without all the negative effects of retinol (peeling, itching skin). Will purchase again…and again.

  2. Margaret L.

    Loving the Retinoid serum. It is just so gentle yet effective. I cannot belive how my skin is glowing from single use.

  3. Antonia I.

    I rarely find a product that actually does what it says. I was so surprised when I tried the Retinoid Serum as a free sample with my previous order. It really softened lines around my eyes and mouth, so of course I purchased the full size bottle. My skin is looking incredible!

  4. Lia K.

    Absolutely my favourite serum which I use at night and the Skin Optimized Vitamin C Serum during the day. I swapped all other serums for this and it is so affordable!

  5. Gwen

    I have used this Retinoid Serum for a few years. It readily absorbs into my skin and leaves my skin feeling so smooth. It’s the only night serum that I use and I love it. I use the Mineral Enriched Balm Concentrate right after for a radiant glow!

  6. Leslie

    This is the best retinol product I have ever tried. I actually think its more effective than my prescription Vitamin A Acid that contains a bunch of chemicals and preservatives that aren’t doing my skin any favors. This serum works fast and is actually good for my skin and the microbome. Love it!

  7. Landon

    Incredible serum. Works wonders on my fine lines and saggy skin. A face lift in a bottle 😉

  8. Valerie W.

    I LOVE LOVE LOVE this serum! It is non-irritating to my super sensitive skin and delivers what it promises! I have tried a lot of high end skincare and this is the best. A facial in a bottle. Plus the price is really reasonable for what this bottle can do!

  9. Fanny

    The Retinoid Serum is just incredible. The magic worked on me from the first try. I saw immediate glow and smoothness to the skin surface. Obviously I need to use it longer for best results, but 1 week in I am seriously impressed!

  10. Ed

    Best retinoid serum. I cannot belive how effective it is and that it doesn’t contain any toxic ingredients. Great job NuVsio!

  11. Jillian S.

    Amazing almost immediate results! My skin is radiant and glowing. I love this Retinoid so much, especially with the Mineral Enriched Balm Concentrate. My skin is like silk!!

  12. Jessie W.

    Nuvsio is always skin perfection, and this is no exeption. My skin looks like its been photoshopped and I use the Retinoid Serum every single night. I use more on my sun spots to fade them quicker. Then seal with the Mineral Enriched Balm Concentrate of course, just as the doctor ordered (hehe). I highly recommend it!

  13. Pauline S.

    Where are my fine lines and wrinkles? Who cares, they are gone and my skin is smooth and flawless thanks to the retinoid serum! I use it nightly and no irritation for me. I love the texture as well, its like my skin just drinks it up and I wake up looking radiant and silky smooth. LOVE IT!

  14. Anie

    I usually take time with the product to write a reveiw, this one though is an exception. I used it a few nights and and wow! I can’t use prescription retinoids because they dry out my skin and make it super red and inflammed. This Retinoid serum doesn’t make my skin angry, it actually somehow calms it and makes it baby soft! Now I am waiting for my wrinkles to dissapear :))

  15. Peter

    I love how this Retinoid Serum makes my skin look smooth and even instantly. Its also a big plus that it doesnt have any scent and the packaging is very beautiful.

  16. Jennie

    Absolutely love this Retinoid Serum. My skin improved after about a month of use. I had breakouts and maskne before, now the face is clear and smooth.

  17. Caitlin

    I’ve been using this product for a few months and am loving it! It is the only vitamin C product that doesn’t cause my skin irritation and goes on so smooth and silky soft. I feel it instantly changes my skin, especially when I mix it with Mineral Enriched Balm Concentrate.

  18. Barry S.

    Best retinoid serum I have ever tried. Does not make skin sensitive or peel. Instead the skin looks really healthy and radiant. One of my favorite serums!

  19. Lena L

    Love from the first use!!! My skin feels absolutely incredible thanks to this Serum, I like how it absorbs quickly, which makes it a perfect product for evening before-bed skin care routine! Thank you, Dr. Brei, for creating this amazing product! You are the best!

  20. Boa

    Very nice serum. Doesn’t dry out the skin but makes it glow and plump.

  21. Beilerm

    Best Retinol SERUM I ever tried. No irritation, instant results!

  22. Lia K.

    Wonderful retinoid serum. The only one my skin can tolerate. I have eczema so I am very careful with which retinoid product I choose. This one is great and microbiome friendly 😉

  23. Jupiette T.

    Absolutely wonderful serum. One of the best retinoid / retinol serums I ever used! It gives me glowing smooth skin without all the retinoids side effects. I definitely recommend and I am so happy they upgraded the size from 30 ml to 40 ml!!

  24. Sharyn C.

    Amazing serum. I highly recommend it.

  25. Alda O.

    I just wanted to rave about this incredible serum! It is so wonderful. I love the consistency and how it glides on the skin and absorbs in seconds. The next day you wake up with this incredibly gorgeous skin glow just to die for. I love this serum so much and I am loving the new 40 ml size!

  26. Linda R.

    Retinoid Serum is just fantastic! I use it every night and my skin loves it. No peeling or irritation. FIVE STARS!

  27. Benny W.

    I love the Retinoid Serum! It is so gentle yet effective! I noticed a difference right away. I have been using it 3 months now and my friends and family noticed my glowing skin right away. Breakouts are also less frequent!

  28. Kacey A.

    Skin Optimized Retinoid Serum is the only retinol product you ever need! My skin is looking so good and no irritation! I love how easily it spreads on my face too. Its so gentle that I use it under my eyes 2x a week.

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